Q. No.The use of transgenic animals, to produce relatively large quantities of rare proteins for use in medicine, is sometimes called:
| 1. | therapeutics | 2. | pharming |
| 3. | molecular treatment | 4. | biochemistry |
Recombinant therapeutic [used for treatment] products are available for all the following disorders except:
| 1. | Hemophilia A | 2. | Pituitary dwarfism |
| 3. | Diabetes insipidus | 4. | Anemia due to renal failure |
Prior to the production of recombinant human insulin, diabetic patients could use insulin isolated from cattle. Which of the listed items would not be a drawback to this procedure?
| 1. | Insulin from cattle is slightly different from human insulin, potentially leading to allergic reactions. |
| 2. | Members of some religions consider cattle sacred and thus are unable to use insulin isolated from cattle. |
| 3. | Infectious diseases may be transferred in the isolated insulin. |
| 4. | Despite the relatively stable supply of cattle pancreases from slaughterhouses, insulin isolated from cattle is still relatively expensive and is in, somewhat, limited supply. |
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Which of the following is a human recombinant product that has not replaced products harvested from animal or human sources?
| 1. | Humulin | 2. | Erythropoietin |
| 3. | FSH | 4. | r HGH [growth hormone] |
Which of the following is a recombinant protein?
| 1. | Beta Galactosidase in E.coli | 2. | Insulin in humans |
| 3. | Somatotropin in humans | 4. | Interferon in E. coli |
Which of the following genetically modified product is used to dissolve blood clots in patients with coronary artery disease?
| 1. | streptokinase | 2. | urokinase |
| 3. | tPA | 4. | heparin |
Deficiency of human growth hormone was initially treated with growth hormone derived from:
| 1. | chemicals | 2. | mutant mice |
| 3. | human cadavers | 4. | pigs |
Match each item in Column I with one item in Column II and chose your answer from the codes given below.
|
Column I (recombinant product) |
Column II (application) |
|
I. PDGF II. Interleukines III. Erythropoeitin IV tPA |
1. Immunomodulation 2. Wound healing 3. Clot buster 4. Stimulation of eryhtropoeisis |
Codes:
| I | II | III | IV | |
| 1. | 1 | 2 | 3 | 4 |
| 2. | 2 | 1 | 4 | 3 |
| 3. | 2 | 1 | 3 | 4 |
| 4. | 1 | 2 | 4 | 3 |
If one needs to derive a cDNA of human insulin, which cells should be taken up for extraction?
| 1. | Any cell of the human body as the DNA is the same in all cells |
| 2. | Any nucleated cell of the human body |
| 3. | Beta cells of islets of Langerhans of the human pancreas |
| 4. | WBCs |
A genetically engineered product used in the treatment of anaemia is:
| 1. | erythropoietin | 2. | hemopoietic |
| 3. | ferritin | 4. | transferrin |
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