Q. No.The two polypeptide chains of insulin protein are linked together by:
| 1. | disulfide bonds | 2. | hydrogen bonds |
| 3. | covalent bonds | 4. | ionic bonds |
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Which of these is an accurate description of gene therapy?
| 1. | A form of site directed mutagenesis. |
| 2. | Introduction of cloned genes into living cells to cure disease. |
| 3. | Cloning of a disease gene in order to understand the disease. |
| 4. | All of these. |
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| Assertion (A): | Correction of a gene defect by gene therapy involves delivery of a normal copy of gene into the individual or embryo. |
| Reason (R): | The normal copy of gene delivered takes over the function of and compensates for the non-functional gene. |
| 1. | Both (A) and (R) are false. |
| 2. | (A) is true but (R) is false. |
| 3. | Both (A) and (R) are true but (R) does not explain (A). |
| 4. | Both (A) and (R) are true and (R) explains (A). |
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| Assertion (A): | Deficiency of the enzyme adenosine deaminase causes severe combined immunodeficiency. |
| Reason (R): | This disorder is caused due to the deletion of the gene for adenosine deaminase. |
| 1. | Both (A) and (R) are true but (R) does not explain (A). |
| 2. | (A) is true but (R) is false. |
| 3. | Both (A) and (R) are false. |
| 4. | Both (A) and (R) are true and (R) explains (A). |
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| I: | ADA deficiency is caused due to the deletion of the gene for adenosine deaminase. |
| II: | Bone marrow transplant and enzyme replacement therapy are completely curative. |
| III. | Lymphocytes transformed with cADA gene are permanent cure for the condition. |
| 1. | Only I and II | 2. | Only I |
| 3. | Only II and III | 4. | I, II and III |
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The first clinical gene therapy trial was given in 1990 to a 4 year girl with:
| 1. | Alpha – 1 antitrypsin deficiency |
| 2. | Cystic fibrosis |
| 3. | Adenosine deaminase deficiency |
| 4. | Chronic myeloid leukemia |
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The viruses generally used for gene therapy are:
| 1. | ds DNA virus | 2. | ss DNA virus |
| 3. | Reovirus | 4. | Reterovirus |
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Gene therapy for ADA deficiency has been tried with the help of which of the following vectors?
| 1. | Microinjection | 2. | Liposome |
| 3. | A bacterium | 4. | A retrovirus |
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A possible permanent cure for SCID can be:
| 1. | Enzyme replacement therapy, in which functional ADA is given to the patient by injections. |
| 2. | Bone marrow transplantation. |
| 3. | A functional ADA cDNA (using a retroviral vector) introduced into lymphocytes. |
| 4. | Gene isolated from marrow cells producing ADA is introduced into cells at early embryonic stages. |
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ADA is an enzyme which is deficient in a genetic disorder SCID. What is the full form of ADA?
| 1. | Adenosine deoxyaminase | 2. | Adenosine deaminase |
| 3. | Aspartate deaminase | 4. | Arginine deaminase |
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