- 1(current)
Q. No.Sickle cell anaemia has not been eliminated from the African population because:
1. It is controlled by recessive genes
2. It is not a fatal disease
3. It provides immunity against malaria
4. It is controlled by dominant genes
The genetic change shown in the given figure shows the pathogenesis of:
| 1. | Phenylketonuria | 2. | Cystic fibrosis |
| 3. | Sickle cell anemia | 4. | Thalassemia |
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Given below is the initial amino acids of the beta chain of a haemoglobin molecule. What will be true about this haemoglobin molecule?
| 1. | The RBCs carrying this molecule will undergo sickling at a high oxygen tension |
| 2. | The RBCs carrying this molecule will undergo sickling at a low oxygen tension |
| 3. | There will be a quantitative decrease in the synthesis of this molecule |
| 4. | This is the normal beta chain of the haemoglobin molecule |
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Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Sickle cell anaemia:
| 1. | A | 2. | B |
| 3. | C | 4. | D |
- 1(current)
Q. No.
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