Thalassemia is inherited as a/an ____________ condition.
1. | Autosomal recessive | 2. | Autosomal dominant |
3. | Sex linked recessive | 4. | Sex linked dominant |
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Statement I: | It is an autosome-linked recessive blood disease transmitted from parents to the offspring when both partners are the unaffected carriers for the gene (or heterozygous). |
Statement II: | The defect could be due to either mutation or deletion which ultimately results in a reduced rate of synthesis of one of the globin chains (α and β chains) that make up haemoglobin. |
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Statement I: | α Thalassemia is controlled by a single gene HBB on chromosome 11 of each parent and occurs due to mutation of one or both the genes. |
Statement II: | β Thalassemia is controlled by two closely linked genes HBA1 and HBA2 on chromosome 16 of each parent. |
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1. | The former is a quantitative problem of synthesising too few globin molecules while the latter is a qualitative problem of synthesising an incorrectly functioning globin. |
2. | The former is a qualitative problem of synthesising too few globin molecules while the latter is a quantitative problem of synthesising an incorrectly functioning globin. |
3. | Both disorders are qualitative problems of synthesising too few globin molecules. |
4. | Both disorders are quantitative problems of synthesising too few globin molecules. |
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