- 1(current)
Q. No.Sickle cell anaemia results from:
1. A chromosomal aberration
2. Non-disjunction of autosome
3. A point mutation
4. Blood transfusion reaction
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The point mutation in sickle cell anaemia leads to a change in the codon. Identify the correct change:
| 1. | UGA to UAA | 2. | GUG to GAG |
| 3. | GAG to GUG | 4. | UAA to UGA |
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Which of the following amino acid substitution in the beta chain of the haemoglobin molecule leads to the development of sickle cell anaemia?
1. Arginine by tyrosine
2. Tyrosine by phenylalanine
3. Valine by Glutamic acid
4. Glutamic acid by Valine
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In sickle cell anaemia, the mutant haemoglobin molecule undergoes:
| 1. | Polymerisation under low oxygen tension causing changes in the shape of the RBC to a sickle-like structure |
| 2. | Depolymerisation under low oxygen tension causing that changes the shape of the RBC to a sickle-like structure |
| 3. | Denaturation under high oxygen tension causing changes in the shape of the RBC to a sickle-like structure |
| 4. | Denaturation |
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| Statement I: | The peptide chain of the haemoglobin molecule that gets mutated leading to the disease is the alpha chain. |
| Statement II: | The mRNA codon X can be GAG and the mRNA codon Y can be GUG. |
2. Only Statement II
3. Both Statement I and Statement II
4. Neither Statement I nor Statement II
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| 1. | The former is a quantitative problem of synthesising too few globin molecules while the latter is a qualitative problem of synthesising an incorrectly functioning globin. |
| 2. | The former is a qualitative problem of synthesising too few globin molecules while the latter is a quantitative problem of synthesising an incorrectly functioning globin. |
| 3. | Both disorders are qualitative problems of synthesising too few globin molecules. |
| 4. | Both disorders are quantitative problems of synthesising too few globin molecules. |
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- 1(current)
Q. No.
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