Q. No.Human skin colour is a polygenic trait. What proportion of progeny in a mating between a male with the genotype AaBbCC and a female with the genotype AaBbCc will have the genotype AABBcc?
1. 0 2. 6/64 3. 15/64 4. 20/64
Study the pedigree given below where filled symbols are individuals affected by a sex-linked dominant genetic disorder:
Which of the following most strongly supports the mode of inheritance given?
1. The progeny of II-1 and II-2 are not affected
2. All female progeny of II-5 are affected
3. 50% male and 50% female progeny of I-1 and I-2 are affected
4. The disorder is seen in all generations
Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Down’s syndrome:
| 1. | A | 2. | B |
| 3. | D | 4. | E |
Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Phenylketonuria:
| 1. | A | 2. | B |
| 3. | C | 4. | D |
Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Klinefelter’s syndrome:
| 1. | A | 2. | B |
| 3. | D | 4. | E |
Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Sickle cell anaemia:
| 1. | A | 2. | B |
| 3. | C | 4. | D |
Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Red-green colour blindness:
| 1. | A | 2. | B |
| 3. | C | 4. | D |
| 1. | 3/16 | 2. | 6/16 |
| 3. | 9/16 | 4. | 1/16 |
| I: | In a test cross, the allele the individual in question [one that expresses the dominant phenotype] passes on, determines the phenotype of the offspring. |
| II: | The homozygous recessive individual can only pass on recessive alleles. |
| 1. | Both I and II are correct and II explains I |
| 2. | Both I and II are correct but II does not explain I |
| 3. | I is correct but II is incorrect |
| 4. | I is incorrect but II is correct |
| Column-I | Column-II | ||
| A. | Homozygous | P. | having two different alleles of a particular gene or genes |
| B. | Heterozygous | Q. | having two identical alleles of a particular gene or genes |
| C. | Homologous | R. | not having the same alleles or genes in the same order of arrangement |
| D. | Heterologous | S. | having the same alleles or genes in the same order of arrangement |
| A | B | C | D | |
| 1. | P | Q | R | S |
| 2. | S | R | Q | P |
| 3. | Q | P | S | R |
| 4. | P | Q | S | R |
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