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What is the major difference between the lagging and leading strands during DNA replication ?

(1) On the leading strand, DNA synthesis occurs from 5' to 3', while DNA synthesis occurs from 3' to 5' on the lagging strand.

(2) DNA polymerase is able to continuously add new nucleotides on the leading strand while it must keep 'starting over' on the lagging strand.

(3) The lagging strand requires only a single primer while the leading strand requires many.

(4) Helicase opens the leading stran at a faster rate than the lagging strand.