Q. No.Who amongst the following scientists had no contribution in the development of the double helix model for the structure of DNA?
1. Rosalind Franklin
2. Maurice Wilkins
3. Erwin Chargaff
4. Meselson and Stahl
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DNA is a polymer of nucleotides which are linked to each other by 3’-5’ phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?
1. Replace purine with pyrimidines
2. Remove/Replace 3' OH group in deoxy ribose
3. Remove/Replace 2' OH group with some other group in deoxy ribose
4. Both ‘b’ and ‘c’
Discontinuous synthesis of DNA occurs in one strand, because:
| 1. | DNA molecule being synthesised is very long |
| 2. | DNA-dependent DNA polymerase catalyses polymerisation only in one direction (5’ → 3’) |
| 3. | it is a more efficient process |
| 4. | DNA ligase joins the short stretches of DNA |
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Which of the following steps in transcription is catalysed by RNA polymerase?
1. Initiation
2. Elongation
3. Termination
4. All of the above
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Control of gene expression in prokaryotes take place at the level of:
1. DNA-replication
2. Transcription
3. Translation
4. None of the above
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Which of the following statements is correct about the role of regulatory proteins in transcription in prokaryotes?
| 1. | They only increase the expression |
| 2. | They only decrease the expression |
| 3. | They interact with RNA polymerase but do not affect the expression |
| 4. | They can act both as activators and as repressors |
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Which was the last human chromosome to be completely sequenced:
1. Chromosome 1
2. Chromosome 11
3. Chromosome 21
4. Chromosome X
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Which of the following are the functions of RNA?
| 1. | It is a carrier of genetic information from DNA to ribosomes synthesising polypeptides. |
| 2. | It carries amino acids to ribosomes. |
| 3. | It is a constituent component of ribosomes. |
| 4. | All of the above |
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While analysing the DNA of an organism a total number of 5386 nucleotides were found out of which the proportion of different bases were: Adenine = 29%, Guanine = 17%, Cytosine = 32%, Thymine = 17%. Considering Chargaff’s rule it can be concluded that:
| 1. | it is a double-stranded circular DNA |
| 2. | It is single-stranded DNA |
| 3. | It is a double-stranded linear DNA |
| 4. | No conclusion can be drawn |
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A gene encoding for a polypeptide of 50 amino acids gets mutated at 25 codons UAU becoming UAA. The result would be:
| 1. | Polypeptide of 24 amino acid |
| 2. | Two polypeptides one with 24 amino acids and the second with 25 amino acids |
| 3. | A polypeptide with 49 amino acid |
| 4. | A polypeptide of 25 amino acids |
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