Colchicine is an alkaloid derived from the autumn crocus. It inhibits mitosis by inhibiting microtubule polymerization. Microtubules are long polymers made of smaller units (monomers) of the protein tubulin. Microtubules are created during normal cell functions by assembling (polymerizing) tubulin components, and are disassembled when they are no longer needed. One of the important functions of microtubules is to move and separate chromosomes and other components of the cell for cell division (mitosis). Colchicine interfere with the assembly and disassembly of tubulin into microtubule polymers as it binds to tubulin. This interrupts cell division, usually during the mitosis (M) phase of the cell cycle when two sets of fully formed chromosomes are supposed to separate into daughter cells