Amoeba reproduces primarily by binary fission. However, a method known as multiple fission is adopted by the unicellular organism Amoeba to survive and reproduce under unfavourable conditions. When the conditions are unfavourable, Amoeba withdraws its pseudopodia and becomes almost round.

Plasmodium reproduces by multiple fission.

Transverse binary fission is the commonest type of asexual reproduction in Paramecium.

Longitudinal binary fission occurs in the euglena.