A permanent cure for ADA deficiency could be:
1. | Enzyme replacement therapy |
2. | Bone marrow transplant |
3. | Introduction of a functional ADA cDNA into lymphocytes |
4. | Introduction of gene isolated from marrow cells producing ADA into early embryonic cells |
If gene isolate from marrow cells producing ADA is introduced into cells at early embryonic stage, it could be a permanant cure of ADA deficiency because the early embryonic cells :
1. Are more differentiated than the later stage cells
2. Are constantly dividing and do not get differentiated
3. Are easy to manipulate than the later stage cells
4. Are virtually immortal
Which kind of therapy was given in 1990 to a four-year-old girl with Adenosine Deaminase (ADA) deficiency?
(1) Gene therapy
(2) Chemotherapy
(3) Immunotherapy
(4) Radiation therapy
The genetic defect-Adenosine Deaminase (ADA) deficiency may be cured permanently by
(1) periodic infusion of genetically engineered lymphocytes having functional ADA cDNA
(2) administering adenosine deaminase activators
(3) introducing bone marrow genes producing ADA into cells at early embryonic stages
(4) enzyme replacement therapy
An example of gene therapy is
(1) production of injectable hepatitis B vaccine
(2) production of vaccines in food crops like potatoes which can be eaten
(3) introduction of gene for adenosine deaminase in persons suffering from Severe Combined Immuno-deficiency (SCID)
(4) production of test tube babies by artificial insemination and implantation of fertilized eggs.
Adenosine deaminase (ADA deficiency) could be permanently cure, if the gene isolated from marrow cells producing ADA is introduced into cell at
(1) early embryonic stages
(2) Late embryonic stages
(3) early childhood
(4) None of the above
The first clinical gene therapy was given for treating
(1) diabetes mellitus
(2) chickenpox
(3) rheumatoid arthritis
(4) adenosine deaminase deficiency
Which technique would you expect to be completely curative in SCID?
(1) Gene therapy in adult stage
(2) Gene therapy in embryonic stage
(3) Bone marrow transplantation
(4) Enzyme replacement therapy
Match the following :-
Column-I | Column-II | ||
I. | Biopiracy | (A) | Gene therapy |
II. | Retroviral vector materials | (B) | Illegal removal of biological |
III. | Biopatent entities | (C) | Right granted for biological |
IV. | Kohler and Milstein | (D) | Monoclonal antibody |
1. I - B, II - A, III - D, IV - C
2. I - B, II - A, III - C, IV - D
3. I - B, II - C, III - A, IV - D
4. I - D, II - A, III - B, IV - C
Gene therapy is not
(1) An attempt to correct a gene defect
(2) By which genes are inserted into an individual or embryo to take over the function of and compensate the non-functional gene.
(3) Genes are inserted into a person's cells and tissues to treat a disease
(4) Correction of environmental defect by inserting a gene