What is incorrect for Hemophilia?

1. In this disease, a single protein that is a part of the cascade of proteins involved in the clotting of blood is affected.

2. In an affected indlvidual a simple cut will result in non-stop bleeding.

3. The heterozygous female (carrier) for haemophilia may transmit the disease to sons.

4. The possibility of a female becoming a haemophilic is extremely rare because mother of such a female has to be hemophilic and the father should be a carrier.

Which of the following most appropriately describes haemophilia?

(1) X-linked recessive gene disorder

(2) Choromosomal disorder

(3) dominant gene disorder

(4) Recessive gene disorder

The incorrect statement with regard to haemophilia is

(1) it is a sex-linked disease

(2) it is a recessive disease

(3) it is a dominant disease

(4) a single protein involved in the clotting of blood effected

Given below is a highly simplified representation of the human sex chromosomes from a karyotype.

The gene a and b could be of

(1) colour blindness and body height

(2) attached ear lobe and Rhesus blood group

(3) haemophilia and red-green colour blindness

(4) phenylketonuria and haemophilia

Which is genetically not possible?

(1) Hemophilic father transfers the hemophilic gene to his son

(2) Hemophiic father transfers the hemophilic gene to his daughter

(3) Carrier mother transfers the hemophilic gene to her son

(4) Carrier mother trannsfers the hemophilic gene to her daughter

If a haemophilic female who marries a normal male gives birth to a male child, then what are the chances of boy being normal? (a hypothetical situation but it won’t happen practically)

 (1) 0%

 (2) 50 %

 (3) 25%

 (4) 75%

Which of the following is the sex linked disease? 

(1) Sickle cell anaemia

(2) Haemophilia

(3) Cystic fibrosis

(4) Phenylketonuria

Which of the following disorder is associated with Queen Victoria?

(1) Sickle cell anaemia

(2) Haemophilia

(3) Huntington's Disease

(4) Myotonic dystrophy

Which of the following amino acid substitution in the beta chain of the haemoglobin molecule leads to the development of sickle cell anaemia?
1. Arginine by tyrosine                  2. Tyrosine by phenylalanine
3. Valine by Glutamic acid             4. Glutamic acid by Valine

A man suffering from haemophilia marries a normal woman without any history of haemophilia in her family. What percentage of their sons are affected?

1. 100%

2. 75%

3. 50% 

4. 0%