Q. No.Choose the correct option regarding Retrovirus:
| 1. | An RNA virus that synthesises DNA during infection |
| 2. | A DNA virus that synthesises RNA during infection |
| 3. | A ssDNA virus |
| 4. | A dsRNA virus |
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A direct target for gene therapy would include all the following cells except:
| 1. | erythrocytes | 2. | muscle fibers |
| 3. | hepatocytes | 4. | vascular endothelium |
The first recombinant therapeutic product approved for human use was:
| 1. | Humulin | 2. | hGH |
| 3. | Factor VIII clotting factor | 4. | Erythropoietin |
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The first clinical gene therapy was done for the treatment of:
| 1. | AIDS |
| 2. | Cancer |
| 3. | Cystic fibrosis |
| 4. | SCID (Severe Combined Immuno Deficiency) resulting from deficiency of ADA |
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Electroporation is:
| 1. | the process of separating charged molecules through a gel maintained in an electric field |
| 2. | the process of combining foreign DNA to an electrically charged vector molecule |
| 3. | the process of introducing DNA into cells by the application of high-voltage pulses |
| 4. | the process of protoplast fusion by the application of high-voltage pulses |
Which of the following genetic disease would be amenable to genetic engineering?
| 1. | Down's syndrome | 2. | Muscular dystrophy |
| 3. | Cystic fibrosis | 4. | Cri du Chat |
1. An antacid
2. An enzyme
3. Used to treat arthritis
4. Used to treat emphysema
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Which of the following is one of the technical reasons why gene therapy is problematic?
| 1. | Most cells with an engineered gene do not produce gene products. |
| 2. | Most cells with engineered genes overwhelm other cells in a tissue. |
| 3. | Cells with transferred genes are unlikely to replicate. |
| 4. | Transferred genes may not have appropriately controlled activity. |
| I: | Diseases such as sickle cell disease that are caused by autosomal recessive disorders may be a good candidate for gene therapy treatment. |
| II: | For such disorders, a person's normal phenotype or cell function may be restored in cells that have the disease by a normal copy of the gene that is mutated. |
| 1. | Both I and II are correct and II explains I |
| 2. | Both I and II are correct but II does not explain I |
| 3. | I is correct but II is incorrect |
| 4. | Both I and II are incorrect |
| Assertion(A): | Delivery of ADA cDNA into lymphocytes is not a permanent cure for ADA deficiency |
| Reason(R) | Lymphocytes do not express ADA gene. |
| 1. | Both (A) and (R) are True and (R) is the correct explanation of the (A) |
| 2. | Both (A) and (R) are True but (R) is not the correct explanation of the (A) |
| 3. | (A) is True but (R) is False |
| 4. | Both (A) and (R) are False |
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