- 1(current)
Q. No.The two polypeptide chains of insulin protein are linked together by:
| 1. | disulfide bonds | 2. | hydrogen bonds |
| 3. | covalent bonds | 4. | ionic bonds |
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Which of these is an accurate description of gene therapy?
| 1. | A form of site directed mutagenesis. |
| 2. | Introduction of cloned genes into living cells to cure disease. |
| 3. | Cloning of a disease gene in order to understand the disease. |
| 4. | All of these. |
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| I: | ADA deficiency is caused due to the deletion of the gene for adenosine deaminase. |
| II: | Bone marrow transplant and enzyme replacement therapy are completely curative. |
| III. | Lymphocytes transformed with cADA gene are permanent cure for the condition. |
| 1. | Only I and II | 2. | Only I |
| 3. | Only II and III | 4. | I, II and III |
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The first clinical gene therapy trial was given in 1990 to a 4 year girl with:
| 1. | Alpha – 1 antitrypsin deficiency |
| 2. | Cystic fibrosis |
| 3. | Adenosine deaminase deficiency |
| 4. | Chronic myeloid leukemia |
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The viruses generally used for gene therapy are:
| 1. | ds DNA virus | 2. | ss DNA virus |
| 3. | Reovirus | 4. | Reterovirus |
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A possible permanent cure for SCID can be:
| 1. | Enzyme replacement therapy, in which functional ADA is given to the patient by injections. |
| 2. | Bone marrow transplantation. |
| 3. | A functional ADA cDNA (using a retroviral vector) introduced into lymphocytes. |
| 4. | Gene isolated from marrow cells producing ADA is introduced into cells at early embryonic stages. |
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A probe which is a molecule used to locate homologous sequences in a mixture of DNA or RNA molecules could be:
| 1. | A ssRNA | 2. | A ssDNA |
| 3. | Either RNA or DNA | 4. | Can be ssDNA but not ssRNA |
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- 1(current)
Q. No.
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