Which of the following statements regarding enzyme inhibition is correct?

1. Competitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein

2. Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme

3. Non-competitive inhibition of an enzyme can be overcome by adding large amount of substrate

4. Non-competitive inhibitors often bind to the enzyme irreversibly 

 

Subtopic:  Enzyme Inhibition: Introduction |
 79%
From NCERT
To view explanation, please take trial in the course.
NEET 2025 - Target Batch
Hints
Links
To view explanation, please take trial in the course.
NEET 2025 - Target Batch

In competitive inhibition:

(1) Inhibitor resembles the substrate in molecular structure

(2) Competition between substrates and inhibitors to occupy active sites

(3) Binding the inhibitors to activities sites declines the enzyme action

(4) All are correct

Subtopic:  Enzyme Inhibition: Introduction | Enzyme Inhibition |
 92%
From NCERT
To view explanation, please take trial in the course.
NEET 2025 - Target Batch
Hints
Links
To view explanation, please take trial in the course.
NEET 2025 - Target Batch

The inhibition of succinic dehydrogenase by malonate is an example of

1. competitive inhibition

2. non-competitive inhibition

3. allosteric modulation

4. none of the above

Subtopic:  Enzyme Inhibition: Introduction | Enzyme Inhibition |
 92%
From NCERT
To view explanation, please take trial in the course.
NEET 2025 - Target Batch
Hints
Links
To view explanation, please take trial in the course.
NEET 2025 - Target Batch

The adjoining graph shows change in conc. of substrate on enzyme activity. Identify A, B and C:

 

A

B

C

(1)

Ki

Km

Vmax

(2)

Vmax2

Km

Ki

(3)

Vmax

Km

Vmax2

(4)

Km

Vmax

Vmax2
Subtopic:  Enzyme Inhibition: Introduction | Enzyme Inhibition |
 87%
From NCERT
To view explanation, please take trial in the course.
NEET 2025 - Target Batch
Hints
Links
To view explanation, please take trial in the course.
NEET 2025 - Target Batch

Select the option which is not correct with respect to enzyme action.

1. Substrate binds with enzyme as its active site

2. Addition of lot of succinate does not reverse the inhibition of succinic dehydogenase by malonate.

3. A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate

4. Malonate is a competitive inhibitor of succinic dehydrogenase

Subtopic:  Enzyme Inhibition: Introduction | Enzyme Inhibition |
 68%
From NCERT
To view explanation, please take trial in the course.
NEET 2025 - Target Batch
Hints
Links
To view explanation, please take trial in the course.
NEET 2025 - Target Batch