Select the option which is not correct with respect to enzyme action:

1. Substrate binds with enzyme at its active site

2. Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate

3. A non- competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate

4. Malonate is a competitive inhibitor of succinic dehydrogenase

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