How sickle cell anaemia is different from Thalassemia?

(1) Being autosomal recessive

(2) Being a blood disease

(3) Being a qualitative disorder

(4) Involvement of mutation

The basis of Thalassemia classification can be-

(1) Which parent is affected

(2) Which chain of haemoglobin molecule is affected

(3) How much a chain is affected

(4) Which gender is showing the disease

The distance between gene A, B, C and D on a chromosome is as follows:

A and C - 18 units

A and B - 26 units

A and D - 40 units

B and C - 8 units

B and D – 14 units

The sequence of these genes would be-

1. ABCD
2. ACBD
3. ADCB
4. ACDB

Read the following statements with respect to Thalassemia and find the wrong one.

1. Quantitative disorder
2. Different forms of Thalassemia are observed
3. Anaemia is not a characteristic feature of this disease
4. Defect due to mutation and deletion

Alpha Thalassemia is controlled by ------- on chromosome number----

(1) Linked gene, 11

(2) Linked gene, 16

(3) Unlinked gene, 11

(4) Unlinked gene, 16

Which of the following are correct with respect to Thalassemia?

1. An autosomal dominant disorder
2. Defect due to mutation or deletion
3. Parents will be homozygous for thalassemia
4. Occurs due to vitamin deficiency

Which of the following is an autosomal recessive blood disease?

1. Phenylketonuria
2. Thalassemia
3. Haemophilia
4. Muscular dystrophy

Which of the following statements is wrong with respect to beta Thalassemia?

1. Controlled by a single gene.
2. Gene involved is HBA1
3. Gene involved is present on chromosome number 11
4. Occurs due to mutation

In a test cross of F1 generation, having a genotype AaBb, following progeny were obtained

AaBb- 450

aabb – 450

Aabb- 50

aaBb- 50

How far in centimorgans are the a and b genes?

a.100

b.90

c.10

d.1