Acrosomal reaction of the sperm occurs due to
 

1. its contact with zona pellucida of the ova
2. reactions within the uterine environment of the female
3. reactions within the epididymal environment of the male
4. androgens produced in the uterus 


(C) One of the three glycoproteins (ZP3), functions as a sperm receptor and binds to a complementary molecule on the surface of the sperm head. Binding of the sperm head to the receptor molecule ZP3 induces the acrosome of the sperm to release iis hydralytic enzymes (sperm lysins). 
The sperm lysins include
(i) Hyaluronidase, thal hydrolyses hyaluronic acid of the tollicutar cells.
(ii) Garona penetrating enzyme dissolves corona radiata portion around the secondary oocyte by hydrolysing their ground substances.
(iii) Zona lysine or acrosin that helps to digest zona pellucida.
All these enzymes dissolve the corona radiata and zona pellucida and enable the sperm to react Ihe plastria membrane of the egg. The above changes in the head of sperm are called acrosome reaction,