Q. 36 What is a recombinant DNA vaccine? Give two examples.

Recombinant DNA vaccines are produced by using genetically ongineered plasmids that have gene inserts possessing the surface proteins of a pathogen. After the binding of pathogens to these surface proteins, a weak immune response is elicited but it do not

results in infection.

These plasmids are inserted in bacteria or yeast cells that expresses the viral proteins, which are then injected into the human host as vaccine, where they are recognised as foreign and an immune response is elicited.

Recombinant hepatitis-B vaccine and polio vaccine are the examples.