Given below are two statements: 

Assertion (A): Non-competitive inhibitor inhibits the catalytic activity of the enzyme by binding with its active site.
Reason (R): Non-competitive inhibitor changes the shape of the active site in such a way that the substrate can't recognize it.
 
1. Assertion and reason both are correct statements but reason does not explain assertion.
2. Assertion and reason both are correct and reason explains the assertion.
3. Assertion is the wrong statement reason is the correct statement.
4. Assertion is the correct statement reason is the wrong statement.

Assertion is the wrong statement reason is the correct statement. Correct assertion Non-competitive inhibitor inhibits the catalytic activity by binding the enzyme at allosteric sile.