- 1(current)
Q. No.The first clinical gene therapy was given in 1990 to a 4-year old girl with:
| 1. | X-linked severe combined immunodeficiency |
| 2. | Adenosine deaminase (ADA) deficiency |
| 3. | Purine nucleoside phosphorylase deficiency |
| 4. | Omenn syndrome |
Subtopic: Gene Therapy |
98%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
Which enzyme was targetted during the first clinical gene therapy given in 1990 to a four year- old girl?
| 1. | Monoamine oxidase |
| 2. | Tyrosine oxidase |
| 3. | Pyruvate dehydrogenase |
| 4. | Adenosine deaminase |
Subtopic: Gene Therapy |
98%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
Match column I with column II and choose the correct option.
| Column I | Column II | ||
| (a) | SCID | (i) | C-peptide |
| (b) | Rosie | (ii) | \(\alpha\)-1-antitrypsin |
| (c) | Proinsulin | (iii) | Human alpha-lactalbumin |
| (d) | Emphysema | (iv) | ADA deficiency |
| 1. | (a)-(iv) | (b)-(iii) | (c)-(i) | (d)-(ii) |
| 2. | (a)-(iii) | (b)-(i) | (c)-(iv) | (d)-(ii) |
| 3. | (a)-(ii) | (b)-(iii) | (c)-(iv) | (d)-(i) |
| 4. | (a)-(iv) | (b)-(iii) | (c)-(ii) | (d)-(i) |
Subtopic: Med Applications & Humulin | Gene Therapy |
93%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
An example of gene therapy is
| 1. | Production of antibodies and vaccines in transgenic plants like banana and tomato |
| 2. | Delay in flower senescence and fruit ripening in Flavr Savr transgenic tomatoes which have longer shelf life |
| 3. | Introduction of the gene for the synthesis of ADA (adenosine deaminase) into a person suffering with SCID |
| 4. | Transfer of nitrogen fixing genes (‘nif’ genes) into plants that are unable to fix atmospheric nitrogen, example cereals |
Subtopic: Gene Therapy |
93%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
The technique of replacing a defective mutant allele with a functional one in an individual's cells to treat hereditary diseases is know as
1. Molecular diagnostics
2. Genetic modification
3. Gene therapy
4. Gene cloning
Subtopic: Gene Therapy |
92%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
Evaluate the following statements and determine how many are correct:
1. Only Statement I is correct.
2. Only Statements II is correct.
3. Both Statements are correct.
4. Both Statements are incorrect.
| Statement I: | Gene therapy involves the insertion of a functional gene into the genome of an individual's cells to treat genetic disorders. |
| Statement II: | Human insulin for diabetic patients is now commonly produced by introducing the human insulin gene into bacterial cells, such as E. coli. |
2. Only Statements II is correct.
3. Both Statements are correct.
4. Both Statements are incorrect.
Subtopic: Med Applications & Humulin | Gene Therapy |
91%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
The genetic defect adenosine deaminase (ADA) deficiency may be cured permanently by:
| 1. | introducing bone marrow cells producing ADA into cells at early embryonic stages |
| 2. | enzyme replacement therapy |
| 3. | periodic infusion of genetically engineered lymphocytes having functional ADA c-DNA |
| 4. | administering adenosine deaminase activators |
Subtopic: Gene Therapy |
89%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
The site of production of ADA in the body is:
1. erythrocytes
2. lymphocytes
3. blood plasma
4. osteocytes
Subtopic: Gene Therapy |
87%
Level 1: 80%+
Hints
The deletion of the gene for enzyme adenosine deaminase results in severe immunodeficiency as
| 1. | Deficiency of this enzyme causes Addison’s disease |
| 2. | Parkinson’s disease is caused due to deficiency of this enzyme |
| 3. | This enzyme is crucial for immune system to function |
| 4. | Eosinophils fail to respond in allergic reactions in absence of gene for adenosine deaminase |
Subtopic: Gene Therapy |
83%
Level 1: 80%+
Please attempt this question first.
Hints
Please attempt this question first.
Which of the following is commonly used as a vector for introducing a DNA fragment in human Lymphocytes?
1. Retrovirus
2. Ti plasmid
3. λ phage
4. pBR 322
Subtopic: Gene Therapy |
84%
Level 1: 80%+
Hints
- 1(current)
Q. No.
© 2026 GoodEd Technologies Pvt. Ltd.