The family pedigree of Queen Victoria shows a number of haemophilic descendants as she was:
| 1. | Affected by the disease |
| 2. | Carrier for the disease |
| 3. | Did not carry the allele for haemophilia |
| 4. | Was not a queen |
Which of the following most appropriately describes haemophilia?
| 1. | X-linked recessive gene disorder |
| 2. | Chromosomal disorder |
| 3. | Dominant gene disorder |
| 4. | Recessive gene disorder |
| Disorder | Characteristics | ||
| A. | Haemophilia | 1. | Autosomal recessive; deficiency of enzyme converting phenylalanine to tyrosine |
| B. | Phenylketonuria | 2. | X-linked recessive; defect in blood clotting protein |
| C. | Sickle-cell anaemia | 3. | Autosomal recessive; quantitative problem - too few globin chains synthesized |
| D. | Thalassemia | 4. | Autosomal recessive; qualitative problem - Glu→Val substitution in \(\beta\)-globin |
| 1. | A-2, B-1, C-4, D-3 | 2. | A-1, B-2, C-3, D-4 |
| 3. | A-3, B-4, C-1, D-2 | 4. | A-4, B-3, C-2, D-1 |
| A: | The possibility of a female becoming a haemophilic is extremely rare. |
| B: | X-linked recessive trait shows transmission from carrier female to male progeny. |
| 1. | Only A is correct |
| 2. | Only B is correct |
| 3. | Both A and B are correct |
| 4. | Both A and B are incorrect |
| 1. | Y-linked recessive allele |
| 2. | X-linked recessive allele |
| 3. | Autosomal recessive allele |
| 4. | X-linked dominant allele |
| Assertion(A): | Normal father and carrier mother can transfer haemophilia to son. |
| Reason(R): | Gene of haemophilia is located on autosome |
| 1. | Both (A) and (R) are True and (R) is the correct explanation of (A) |
| 2. | Both (A) and (R) are True and (R) is not the correct explanation of (A) |
| 3. | (A) is True but (R) is False |
| 4. | Both (A) and (R) are False |
Which of the following is not a hereditary disease:
| 1. | Haemophilia | 2. | Cretinism |
| 3. | Cystic fibrosis | 4. | Thalasasemia |