The C - peptide is:

1. Not present in proinsulin.

2. Present in mature insulin.

3. Removed during maturation of insulin.

4. Also present in artificial insulin.

Which of the following is wrongly matched in the given table?

1. i and ii

2. ii, iii and iv

3. ii and iii

4. Only iii

Which is not true about PCR (Polymerase Chain Reaction) ?

1. PCR can amplify very small amount of DNA

2. It can be used to detect HIV in suspects

3. Only RNA can be used as primer

4. Used to detect mutation in genes

Which one of the following statement about genetically engineered insulin is incorrect:

1. E.coli is used for producing humulin

2. Chain A, B were produced separately

3. Eli lily company prepared it for first time

4. Genetically engineered insulin has C peptide

Match the columns -

1. A-ii, B-iii, C-iv, D-i

2. A-i, B-iii, C-iv, D-ii

3. A-ii, B-iii, C-i, D-iv

4. A-iv, B-iii, C-ii, D-i

Match the following

           Column I         Column II

(A) $\mathrm{\alpha }$-1 antitrypsin         (i) SCID

(B) C-peptide                (ii) Emphysema

(C) Human lactalbumin  (iii) Rosie

(D) ADA deficiency        (iv) Proinsulin

       A   B   C    D

1.  (i) (ii) (iii) (iv)

2.  (ii) (iv) (i) (iii)

3.  (iii) (iv) (ii) (i)

4.  (ii) (iv) (iii) (i)

RNA interference (RNAi) inhibits

1. DNA replication

2. Neither transcription nor translation of specific genes

3. Transcription of all genes

4. Translation of specific mRNAs

RNAi is a method of gene silencing, which when done in tobacco plant to prevent infestation by Meloidogyne incognita may involve all except

1. Agrobacterium as vector

2. Introduction of single stranded RNA into host cells

3. Transposons that replicate via RNA intermediate

4. Silencing of mRNA to stop translation

Which of the following statement is incorrect? 

1. Golden rice in vitamin A

2. Human protein $(\alpha -1 antitryp\sin )$ obtained from transgenic animals is used to treat emphysema

3. Human protein-enriched milk, which contained the human alpha-lactalbumin was produced by the transgenic cow, Molly 

4. TPA (Tissue Plasminogen Activator) is used by doctors to dissolve clots after a heart attack in patients 

All of the following statements are correct in respect of gene therapy, except

1. It allows correction of genetic defect in embryonic stage only 

2. The gene is inserted into cells and tissues to treat a disease

3. Delivery of a normal gene into cell takes over the function of and compensate for the non-functional gene 

4. As a step towards gene therapy to treat ADA deficiency, ADAcDNA is introduced into cultured lymphocytes of the patient and subsequently returned to him/her.