The first clinical gene therapy was given for treating:
1. Chickenpox
2. Rheumatoid arthritis
3. Adenosine deaminase deficiency
4. Diabetes mellitus
The genetic defect-Adenosine Deaminase (ADA) deficiency may be cured permanently by:
| 1. | periodic infusion of genetically engineered lymphocytes having functional ADA cDNA |
| 2. | administering adenosine deaminase activators |
| 3. | introducing bone marrow cells producing ADA into cells at early embryonic stages |
| 4. | invitro cell culture therapy |