Select the option which is not correct with respect to enzyme action:
1. Substrate binds with enzyme at its active site.
2. Addition of a lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.
3. A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.
4. Malonate is a competitive inhibitor of succinic dehydrogenase.