Q. No.The first drug produced using recombinant DNA technology is used to treat:
| 1. | haemophilia | 2. | dwarfism |
| 3. | immunodeficiency | 4. | diabetes |
Subtopic: Â Med Applications & Humulin |
 70%
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C-peptide of human insulin is:
| 1. | A part of mature insulin molecule |
| 2. | Responsible for formation of disulphide bridges |
| 3. | Removed during maturation of pro-insulin to insulin |
| 4. | Responsible for its biological activity |
Subtopic: Â Med Applications & Humulin |
 94%
From NCERT
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The main challenge for production of insulin using rDNA techniques was:
| 1. | to find a suitable host cell that can perform RNA splicing |
| 2. | isolation of a copy of gene from the human DNA |
| 3. | getting insulin assembled into a mature form |
| 4. | downstream processing |
Subtopic: Â Med Applications & Humulin |
 84%
From NCERT
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How many of the given statements regarding insulin are correct?
| I: | All diabetics require insulin from the very beginning. |
| II: | Insulin can be given orally to diabetics. |
| III. | Insulin extracted from pancreas of slaughtered cattle and pigs caused some patients to develop allergy. |
| IV. | Recombinant insulin was first prepared by Indian pharmaceutical giant Ranbaxy. |
| V. | The two polypeptide chains in the final structure of Insulin are joined by disulfide bonds. |
| VI. | DNA sequences corresponding to A and B chains of human insulin were introduced in plasmids of E.coli to produce insulin chains for preparing recombinant insulin. |
| 1. | 2 | 2. | 3 |
| 3. | 4 | 4. | 5 |
Subtopic: Â Med Applications & Humulin |
 58%
From NCERT
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To produce human recombinant insulin, Eli Lilly:
| 1. | prepared two DNA sequences corresponding to A and B chains of human insulin and introduced them into plasmids of E. coli to produce insulin chains. |
| 2. | prepared two DNA sequences corresponding to A and C chains of human insulin and introduced them in plasmids of Yeast to produce insulin chains. |
| 3. | used reverse transcription of the hnRNA transcript of the insulin gene to make complementary DNA. |
| 4. | used fragments created by restriction enzyme digestion to isolate and used the gene for insulin from pancreatic cells. |
Subtopic: Â Med Applications & Humulin |
 92%
From NCERT
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Insulin earlier extracted from pancreas of slaughtered cattle and pigs:
1. Only I is correct
2. Only II is correct
3. Both I and II are correct
4. Both I and II are incorrect
| I: | was not effective at all in bringing blood glucose levels down towards normal range in diabetics. |
| II: | caused some patients to develop allergy or other types of reactions to the foreign protein. |
2. Only II is correct
3. Both I and II are correct
4. Both I and II are incorrect
Subtopic: Â Med Applications & Humulin |
 79%
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The first recombinant therapeutic product approved for human use was:
1. Flavr Savr
2. EPO
3. Human Growth Hormone
4. Human Insulin
1. Flavr Savr
2. EPO
3. Human Growth Hormone
4. Human Insulin
Subtopic: Â Med Applications & Humulin |
 95%
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The plasmid of which of the following bacteria was used to produce human insulin?
1. Salmonella typhimurium
2. Klebsiella pneumoniae
3. Escherichia coli
4. Agrobacterium tumefaciens
1. Salmonella typhimurium
2. Klebsiella pneumoniae
3. Escherichia coli
4. Agrobacterium tumefaciens
Subtopic: Â Med Applications & Humulin |
 88%
From NCERT
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What is an advantage of recombinant insulin over insulin obtained from animal sources?
| 1. | Recombinant insulin is cheaper to produce and more ethical. |
| 2. | It is identical to human insulin, reducing allergic reactions and increasing efficacy. |
| 3. | It can be orally ingested instead of injected. |
| 4. | It has a longer shelf-life. |
Subtopic: Â Med Applications & Humulin |
 91%
From NCERT
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Human insulin produced through recombinant DNA technology:
| 1. | Has a higher risk of causing allergies compared to pig insulin. |
| 2. | Is exactly the same as insulin produced in the human pancreas. |
| 3. | Is produced by inserting the human insulin gene into bacteria. |
| 4. | Requires human cells for production. |
Subtopic: Â Med Applications & Humulin |
 55%
From NCERT
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