In 1928, Frederick Griffith, in a series of experiments with Streptococcus pneumoniae (bacterium responsible for pneumonia), discovered:
1. that DNA is more stable than RNA
2. that DNA is the genetic material for most living organisms
3. the process of bacterial transformation
4. the R and S strains of the bacterium
Subtopic:  Search for Genetic Material |
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Griffith co-injected the heat-killed S and live R strains of Pneumococcus bacterium into the mice and much to his surprise the mice developed pneumonia and died. He concluded that:

I: Live R was transformed into Live S strain as he was able to isolate Live S strain from the blood of the infected mice.
II: Bacterial transformation is a stable and heritable change as the culture of bacteria isolated from dead mice was unable to infect other mice.
 
1. Both I and II are correct
2. Only I is correct
3. Only II is correct
4. Both I and II are incorrect

Subtopic:  Search for Genetic Material |
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Griffith’s transformation experiment in Streptococcus pneumoniae demonstrated that:
1.    Heat-killed virulent bacteria failed to produce disease in mice
2.    Live non-virulent bacteria failed to produce disease in mice
3.    Heat-killed virulent bacteria transformed non-virulent bacteria into virulent form
4.    Live virulent bacteria alone produced fatal infection in mice

Subtopic:  Search for Genetic Material |
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Griffith's experiment discovered bacterial transformation which in his experiment means:

1. A mutation in the R strain made them virulent.
2. A mutation in the S strain made them non-virulent.
3. A rough strain passed genetic information to a smooth strain.
4. A smooth strain passed genetic information to a rough strain.
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Consider the given two statements:
Assertion (A): When Streptococcus pneumoniae (pneumococcus) bacteria are grown on a culture plate, some produce smooth shiny colonies (S) while others produce rough colonies (R).
Reason (R): Mice infected with the S strain (virulent) die from pneumonia infection but mice infected with the R strain do not develop pneumonia.
 
1. Both (A) and (R) are True and (R) correctly explains (A).
2. Both (A) and (R) are True but (R) does not correctly explain (A).
3. (A) is True; (R) is False
4. Both (A) and (R) are False
Subtopic:  Search for Genetic Material |
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Prior to the work of Avery, Macleod, and McCarty, the genetic material was thought to be:

1. DNA 2. RNA
3. Protein 4. Nucleotide
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In Avery, Macleod, and McCarty's experiment, the transformation of bacteria was inhibited by:

1. Proteases 2. RNase
3. DNAs 4. None of these

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Which of the following will directly support the conclusion derived by Oswald Avery, Colin MacLeod and Maclyn McCarty that DNA caused the bacterial transformation in Griffith’s experiment?
I: Protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation
II: Digestion with DNase inhibited transformation.
 
1. Only I 2. Only II
3. Both I and II 4. Neither I nor II
Subtopic:  Search for Genetic Material |
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The Avery, McLeod, and McCarty experiment proved that:
1. Proteins are the hereditary material
2. RNA is the genetic material in viruses
3. DNA is the genetic material
4. Lipids play a crucial role in inheritance
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The unequivocal proof that DNA is the genetic material was provided by:

1. Avery, Macleod, and McCarty
2. Hershey and Chase
3. Meselson and Stahl
4. Watson and Crick

Subtopic:  Search for Genetic Material |
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