- 1(current)
Q. No.Sickle cell anaemia results from:
1. A chromosomal aberration
2. Non-disjunction of autosome
3. A point mutation
4. Blood transfusion reaction
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
89%
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The point mutation in sickle cell anaemia leads to a change in the codon. Identify the correct change:
| 1. | UGA to UAA | 2. | GUG to GAG |
| 3. | GAG to GUG | 4. | UAA to UGA |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
87%
From NCERT
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Which of the following amino acid substitution in the beta chain of the haemoglobin molecule leads to the development of sickle cell anaemia?
1. Arginine by tyrosine
2. Tyrosine by phenylalanine
3. Valine by Glutamic acid
4. Glutamic acid by Valine
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
82%
From NCERT
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In sickle cell anaemia, the mutant haemoglobin molecule undergoes:
| 1. | Polymerisation under low oxygen tension causing changes in the shape of the RBC to a sickle-like structure |
| 2. | Depolymerisation under low oxygen tension causing that changes the shape of the RBC to a sickle-like structure |
| 3. | Denaturation under high oxygen tension causing changes in the shape of the RBC to a sickle-like structure |
| 4. | Denaturation |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
74%
From NCERT
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Given below is the initial amino acids of the beta chain of a haemoglobin molecule. What will be true about this haemoglobin molecule?
| 1. | The RBCs carrying this molecule will undergo sickling at a high oxygen tension |
| 2. | The RBCs carrying this molecule will undergo sickling at a low oxygen tension |
| 3. | There will be a quantitative decrease in the synthesis of this molecule |
| 4. | This is the normal beta chain of the haemoglobin molecule |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
57%
From NCERT
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Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Sickle cell anaemia:
| 1. | A | 2. | B |
| 3. | C | 4. | D |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
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What will be true regarding the comparison of thalassemia and sickle cell anaemia?
| 1. | The former is a quantitative problem of synthesising too few globin molecules while the latter is a qualitative problem of synthesising an incorrectly functioning globin. |
| 2. | The former is a qualitative problem of synthesising too few globin molecules while the latter is a quantitative problem of synthesising an incorrectly functioning globin. |
| 3. | Both disorders are qualitative problems of synthesising too few globin molecules. |
| 4. | Both disorders are quantitative problems of synthesising too few globin molecules. |
Subtopic: Mendelian Disorders: Sickle Cell Anemia | Mendelian Disorders: Thalassemia |
88%
From NCERT
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The β-globin chains of hemoglobin are encoded by:
| 1. | a single gene on chromosome 11 |
| 2. | two closely linked genes on chromosome 16 |
| 3. | a single gene on chromosome 16 |
| 4. | two closely linked genes on chromosome 11 |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
63%
From NCERT
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