Choose the correct option regarding Retrovirus:
1. | An RNA virus that synthesises DNA during infection |
2. | A DNA virus that synthesises RNA during infection |
3. | A ssDNA virus |
4. | A dsRNA virus |
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A direct target for gene therapy would include all the following cells except:
1. | erythrocytes | 2. | muscle fibers |
3. | hepatocytes | 4. | vascular endothelium |
The first recombinant therapeutic product approved for human use was:
1. | Humulin | 2. | hGH |
3. | Factor VIII clotting factor | 4. | Erythropoietin |
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The first clinical gene therapy was done for the treatment of:
1. | AIDS |
2. | Cancer |
3. | Cystic fibrosis |
4. | SCID (Severe Combined Immuno Deficiency) resulting from deficiency of ADA |
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Electroporation is:
1. | the process of separating charged molecules through a gel maintained in an electric field |
2. | the process of combining foreign DNA to an electrically charged vector molecule |
3. | the process of introducing DNA into cells by the application of high-voltage pulses |
4. | the process of protoplast fusion by the application of high-voltage pulses |
Which of the following genetic disease would be amenable to genetic engineering?
1. | Down's syndrome | 2. | Muscular dystrophy |
3. | Cystic fibrosis | 4. | Cri du Chat |
α -1 antitrypsin is:
1. | An antacid | 2. | An enzyme |
3. | Used to treat arthritis | 4. | Used to treat emphysema |
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Which of the following is one of the technical reasons why gene therapy is problematic?
1. | Most cells with an engineered gene do not produce gene products. |
2. | Most cells with engineered genes overwhelm other cells in a tissue. |
3. | Cells with transferred genes are unlikely to replicate. |
4. | Transferred genes may not have appropriately controlled activity. |
Assertion(A): | Delivery of ADA cDNA into lymphocytes is not a permanent cure for ADA deficiency |
Reason(R) | Lymphocytes do not express ADA gene. |
1. | Both (A) and (R) are True and (R) is the correct explanation of the (A) |
2. | Both (A) and (R) are True but (R) is not the correct explanation of the (A) |
3. | (A) is True but (R) is False |
4. | Both (A) and (R) are False |