Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement:
| 1. | Both are due to a quantitative defect in globin chain synthesis |
| 2. | Thalassemia is due to less synthesis of globin molecules |
| 3. | Sickle cell anemia is due to a quantitative problem of globin molecules |
| 4. | Both are due to a qualitative defect in globin chain synthesis |

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