- 1(current)
Q. No.Thalassemia is inherited as a/an ____________ condition.
| 1. | Autosomal recessive | 2. | Autosomal dominant |
| 3. | Sex linked recessive | 4. | Sex linked dominant |
Subtopic: Mendelian Disorders: Thalassemia |
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Level 1: 80%+
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Regarding thalassemia:
1. Statement I is correct, Statement II is correct.
2. Statement I is incorrect, Statement II is correct.
3. Statement I is correct, Statement II is incorrect.
4. Statement I is incorrect, Statement II is incorrect.
| Statement I: | It is an autosome-linked recessive blood disease transmitted from parents to the offspring when both partners are the unaffected carriers for the gene (or heterozygous). |
| Statement II: | The defect could be due to either mutation or deletion which ultimately results in a reduced rate of synthesis of one of the globin chains (α and β chains) that make up haemoglobin. |
2. Statement I is incorrect, Statement II is correct.
3. Statement I is correct, Statement II is incorrect.
4. Statement I is incorrect, Statement II is incorrect.
Subtopic: Mendelian Disorders: Thalassemia |
83%
Level 1: 80%+
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Thalassemia can be classified according to which chain of the haemoglobin molecule is affected.
1. Statement I is correct, Statement II is correct.
2. Statement I is incorrect, Statement II is correct.
3. Statement I is correct, Statement II is incorrect.
4. Statement I is incorrect, Statement II is incorrect.
| Statement I: | α Thalassemia is controlled by a single gene HBB on chromosome 11 of each parent and occurs due to mutation of one or both the genes. |
| Statement II: | β Thalassemia is controlled by two closely linked genes HBA1 and HBA2 on chromosome 16 of each parent. |
2. Statement I is incorrect, Statement II is correct.
3. Statement I is correct, Statement II is incorrect.
4. Statement I is incorrect, Statement II is incorrect.
Subtopic: Mendelian Disorders: Thalassemia |
64%
Level 2: 60%+
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What will be true regarding the comparison of thalassemia and sickle cell anaemia?
| 1. | The former is a quantitative problem of synthesising too few globin molecules while the latter is a qualitative problem of synthesising an incorrectly functioning globin. |
| 2. | The former is a qualitative problem of synthesising too few globin molecules while the latter is a quantitative problem of synthesising an incorrectly functioning globin. |
| 3. | Both disorders are qualitative problems of synthesising too few globin molecules. |
| 4. | Both disorders are quantitative problems of synthesising too few globin molecules. |
Subtopic: Mendelian Disorders: Sickle Cell Anemia | Mendelian Disorders: Thalassemia |
87%
Level 1: 80%+
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- 1(current)
Q. No.
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