Q. No.Which kind of therapy was given in 1990 to a four-year-old girl with Adenosine Deaminase (ADA) deficiency?
| 1. | Gene therapy | 2. | Chemotherapy |
| 3. | Immunotherapy | 4. | Radiation therapy |
A permanent cure for ADA deficiency could be:
| 1. | Enzyme replacement therapy |
| 2. | Bone marrow transplant |
| 3. | Introduction of a functional ADA cDNA into lymphocytes |
| 4. | Introduction of gene isolated from marrow cells producing ADA into early embryonic cells |
Find the incorrect statement.
1. Gene therapy is a genetic engineering technique
used to treat disease at molecular level by
replacing defective genes with normal genes
2. Calcitonin is a medically useful recombinant
product in the treatment of infertility
3. Bt toxin is biodegradable insecticide obtained
from Bacillus thuringiensis
4. Trichoderma sp. is a biocontrol agent for fungal
diseases of plants
The first step of gene therapy would be
| 1. | Culture of the lymphocytes from patient's blood |
| 2. | Using vector for transmitting gene |
| 3. | cDNA was prepared |
| 4. | cDNA was inserted directly into the cells |
Gene therapy is not
| 1. | An attempt to correct a gene defect |
| 2. | By which genes are inserted into an individual or embryo to take over the function of and compensate the non-functional gene. |
| 3. | Genes are inserted into a person's cells and tissues to treat a disease |
| 4. | Correction of environmental defect by inserting a gene |
The last step of gene therapy would be
| 1. | The corrected lymphocytes are returned to the patients |
| 2. | Culture of lymphocytes of the patient |
| 3. | Introduction of correct gene in cultured cells |
| 4. | Removal of corrected lymphocytes from culture |
Which of the following therapies for ADA deficiency are not completely curative?
| 1. | Bone Marrow Transplantation |
| 2. | Enzyme replacement Therapy |
| 3. | Both A and B |
| 4. | Both are completely curative |
The permanent cure of gene therapy can be
| 1. | Cells isolated from bone marrow in an adult were cultured and transformed with corrected gene |
| 2. | Cells isolated from thymus in an adult were cultured and transformed with corrected gene |
| 3. | Cells isolated from bone marrow in an embryo were cultured and transformed with corrected gene |
| 4. | Genes isolated from bone marrow were introduced into the cells at early embryonic stage |
All of the following statements are correct in respect of gene therapy, except
| 1. | It allows correction of genetic defect in embryonic stage only |
| 2. | The gene is inserted into cells and tissues to treat a disease |
| 3. | Delivery of a normal gene into cell takes over the function of and compensate for the non-functional gene |
| 4. | As a step towards gene therapy to treat ADA deficiency, ADAcDNA is introduced into cultured lymphocytes of the patient and subsequently returned to him/her. |
© 2026 GoodEd Technologies Pvt. Ltd.