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Q. No.

Assertion (A): In 1983, Eli Lilly used E.coli, as heterologous host for the production of humulin 
Reason (R): Production of insulin in E.coli by genetic engineering is possible because bacterial cells can carry out the RNA splicing mechanism 
Choose the correct answer from the options given below 
1. Both (A) and (R) are true and (R) is the correct explanation of the (A) 
2. Both (A) and (R) are true but (R) is not the correct explanation of the (A) 
3. (A) is true but (R) us false 
4. (A) is false but (R) is true 

Subtopic:  Med Applications & Humulin |
 57%
Level 3: 35%-60%
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From the list of human diseases given below, which ones have transgenic models existing for them? 
a. Alzheimer's 
b. Rheumatoid arthritis
c. Cystic fibrosis 
d. Cancer 

Select the correct option from the following 
1. b and c only 
2. a only 
3. d and a only 
4. a, b, c and d 
Subtopic:  Transgenic Microbes & Animals |
 86%
Level 1: 80%+
Hints
With regard to insulin choose the incorrect statement(s).
a. C-peptide is found attached with both A and B chains of insulin with the help of disulphide bonds.
b. In 1983, both A and B chains were produced by introducing alien genes in plasmid of same E.coli by Eli Lilly.
c. A-peptide and B-peptide of insulin are interconnected by peptide bonds in mature insulin.
d. Insulin from an animal source may cause allergy or other types of reactions in some diabetic patients.
Choose the correct answer from the options given below.
1. (a) and (b) only
2. (c) and (d)
3. (a), (b) and (c)
4. (d) only
Subtopic:  Med Applications & Humulin |
 59%
Level 3: 35%-60%
Hints
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Assertion (A): Insulin used for diabetes was earlier extracted from the pancreas of slaughtered cattle and pigs but now it is not used.
Reason (R): Aarti along with some other patients took insulin injections in which insulin was from an animal source and they manifested an allergic response to that.
In light of the above statements, select the correct option:
1. Both (A) and (R) are True and (R) is the correct explanation of (A).
2. Both (A) and (R) are True but (R) is not the correct explanation of (A).
3. (A) is True but (R) is False.
4. (A) is False but (R) is True.
Subtopic:  Med Applications & Humulin |
 81%
Level 1: 80%+
Hints
Assertion(A): Functional ADA cDNA genes must be inserted in the lymphocytes at the early embryonic stage to treat SCID.
Reason(R): Cells in the embryonic stage are mortal, differentiated and easy to manipulate.
 
1. Both (A) and (R) are true and (R) is the correct explanation of (A).
2. Both (A) and (R) are true and (R) is not the correct explanation of (A).
3. (A) is true but (R) is false.
4. (A) is False but (R) is true.
Subtopic:  Gene Therapy |
Level 3: 35%-60%
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Assertion(A): We can grow meristem in vitro to get virus-free plants.
Reason(R): Apical and lateral meristems are free of viruses.
Choices for Assertions and reasons:
1. Both (A) and (R) are true and (R) is the correct explanation of (A).
2. Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3. (A) is true, but (R) is false.
4. (A) is false, but (R) is true.
Subtopic:  Plant Tissue Culture |
Level 3: 35%-60%
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Assertion(A): Agrobacterium tumefaciens is popular in genetic engineering because this bacterium is associated with the roots of all cereal and pulse crops.
Reason(R): A gene incorporated in the bacterial chromosomal genome gets automatically transferred to the crop with which the bacterium is associated.
1. Both (A) and (R) are true and (R) is the correct explanation of (A).
2. Both (A) and (R) are true but (R) is not the correct explanation of (A).
3. (A) is true but (R) is false.
4. Both (A) and (R) are false.
Subtopic:  Intro to Agri Applications |
 52%
Level 3: 35%-60%
Hints
Assertion (A): Agrobacterium tumifaciens is common pathogen of plant family poaceae.
Reason (R): Plants of poaceae family are highly sensitive to the bacteria Agrobacterium tumifaciens.
 
1. Both (A) and (R) are True and (R) is the correct explanation of (A).
2. Both (A) and (R) are True but (R) is not the correct explanation of (A).
3. (A) is True but (R) is False.
4. Both (A) and (R) are False.
Subtopic:  Bt Crops | Interference RNA Tech |
 57%
Level 3: 35%-60%
Hints
Assertion(A): Batch fermentation is said to be closed system.
Reason(R): In batch fermentation, the conditions set up are not changed from outside one fermentation starts.

1. Both (A) and (R) are True and (R) is the correct explanation of (A).
2. Both (A) and (R) are True but (R) is not the correct explanation of (A).
3. (A) is True but (R) is False.
4. Both (A) and (R) are False.
Subtopic:  Med Applications & Humulin |
 73%
Level 2: 60%+
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Assertion(A): A gene from Bacillus thuringiensis is incorporated in plant genome to increase their yield.
Reason(R): Bacillus thuringiensis has Bt toxin producing gene, which kills the larva of insects.

1. Both (A) and (R) are True and (R) is the correct explanation of (A).
2. Both (A) and (R) are True but (R) is not the correct explanation of (A).
3. (A) is True but (R) is False.
4. Both (A) and (R) are False.
Subtopic:  Intro to Agri Applications | Bt Crops |
 66%
Level 2: 60%+
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