The premature termination of polypeptide synthesis due to stop codon can be overcome via compensatory mutation in tRNA. This genetic phenomenon is called
(1) extragenic suppression
(2) intragenic suppression
(3) codon bias
(4) true reversion
(1) Extragenic or intergenic suppression reveals the effect of a mutation in a gene at a different place within the genome.
It can be explained as a mutation disrupting the complementary interaction between protein molecules which can be compensated by a second mutation occuring at some place in the genome restoring or providing a suitable alternative interaction between those molecules.