NEET Botany Molecular Basis of Inheritance Questions Solved

Okazaki fragments are proportions of DNA

(1) synthesized on the leading strand of DNA replication fork

(2) synthesized on the lagging strand of DNA replication fork

(3) produced during the digestion of DNA by restriction endonucleases

(4) none of the above

(2) Okazaki fragments are short DNA fragments created on the lagging strand during DNA replication that ar subsequently joined to form a single continuous strand of DNA.

With the synthesis of complimentary DNA strands the  leading strand always reads 3’ to 5’. Its antiparallel compliment strand, the lagging strand reads from 5’ to 3’. Because the original strands of DNA are antiparallel and only one new strand can begin at the 3’ end (the preferred end), the other strand must grow in the opposite direction. Regarding the lagging strand, the result of this strand’s discontigous replication is the production of a series of short sections of DNA called Okazaki fragments. It was originally discovered by Reiji and his wife Tsuneko Okazaki and their colleagues while studying replication of bacteriophage DNA in Escherichia coli.

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