During transcription RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is it’s DNA-binding sequence?
(4) TATA box is present in eukaryotic promoter region. It has a resemblance with pribnow box of prokaryotes. TATA box was identified by Dr. Hogness and so, it is called as Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription the RNA polymerase (a holoenzyme which has a core unit and a sigma factor for proper initiation of transcription) binds to TATA box due to which DNA assumes a saddle like structure at this place.