Q. No.The first human hormone produced by recombinant DNA technology is:
1. Insulin
2. Estrogen
3. Thyroxin
4. Progesterone
1. Human Growth Hormone
2. Erythropoietin
3. Human insulin
4. Factor VIII
Which one of the following is now being commercially produced by biotechnological procedures:
1. Morphine
2. Quinine
3. Insulin
4. Nicotine
| 1. | It is a critical part of mature insulin molecule |
| 2. | It causes antigenic reactions |
| 3. | It is removed during maturation of pro-insulin to insulin |
| 4. | It is responsible for its biological activity. |
Eli Lilly an American company is famous for
| 1. | Producing GH (growth hormone) synthesised by recombinant DNA technology |
| 2. | Preparing two DNA sequences corresponding to A and B chains of human insulin and introduced them in the plasmids of E. coli to produce insulin chains |
| 3. | Producing pest resistant plants, by RNA interference |
| 4. | Producing vitamin ‘A’ enriched rice |
Genetically engineered insulin for human is produced from:
1. Escherichia coli
2. Psuedomonas putida
3. Bacillus thuringiensis
4. Rhizobium meliloti
| 1. | By isolating fully processed insulin from human pancreas and inserting it into bacterial plasmids for direct production. |
| 2. | By modifying plant cells to produce insulin in a single-chain form, which was later folded into its active conformation. |
| 3. | By synthesizing separate DNA sequences for the A and B chains of insulin, inserting them into E. coli, producing them independently, and later combining them through disulfide bonds. |
| 4. | By extracting insulin from genetically modified yeast cells that could assemble the A and B chains inside the cytoplasm. |
The two polypeptides of human insulin are linked together by:
| 1. | hydrogen bonds | 2. | phosphodiester bond |
| 3. | covalent bond | 4. | disulphide bridges |
Read the following statements with respect to genetically engineered insulin and choose the correct answerA. Insulin hormone consists of two shortpolypeptide chains: chain A and chain B, that are linked together by disulphide bridges.B. Chains A and B were produced separately,
extracted and combined by creating disulfide bonds to form human insulin by Eli Lilly
company.
1. Both statements are correct
2. Both statements are incorrect
3. Only statement A is correct
4. Only statement B is correct
| Statement I: | Gene therapy involves the insertion of a functional gene into the genome of an individual's cells to treat genetic disorders. |
| Statement II: | Human insulin for diabetic patients is now commonly produced by introducing the human insulin gene into bacterial cells, such as E. coli. |
2. Only Statements II is correct.
3. Both Statements are correct.
4. Both Statements are incorrect.
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