The length of the DNA molecule greatly exceeds the dimensions of the nucleus in eukaryotic cells. How is this DNA accommodated?
1. Deletion of non-essential genes
2. Super-coiling in nucleosomes
3. DNAse digestion
4. Through the elimination of repetitive DNA
| Statement I: | In prokaryotes, the positively charged DNA is held with some negatively charged proteins in a region called nucleoid. |
| Statement II: | In eukaryotes, the negatively charged DNA is wrapped around the positively charged histone octamer to form nucleosome. |
With respect to nucleosome, which of the following statements is incorrect ?
| 1. | Nucleosome contains 120 bp of DNA helix. |
| 2. | Nucleosomes are seen as 'beads' on string' under Electron Microscope. |
| 3. | DNA is wrapped around positively charged histone octamer to form nucleosome. |
| 4. | Nucleosome is the repeating unit of chromatin. |
Which one of the following statements about Histones is wrong?
| 1. | Histones are rich in amino acids - Lysine and Arginine. |
| 2. | Histones carry a positive charge in the side chain. |
| 3. | Histones are organized to form a unit of 8 molecules |
| 4. | Histones are organized to form a unit of 10 molecules |
The association of histone H1 with a nucleosome indicates:
1. DNA replication is occurring
2. The DNA is condensed into a chromatin fibre
3. The DNA double helix is exposed
4. Transcription is occurring
| List I | List II | ||
| A. | Histones | I. | Loosely packed chromatin |
| B. | Nucleosome | II. | Densely packed chromatin |
| C. | Euchromatin | III. | Positively charged basic proteins |
| D. | Heterochromatin | IV. | DNA wrapped around histone octamer |
| (a) | Euchromatin is loosely packed chromatin. |
| (b) | Heterochromatin is transcriptionally active. |
| (c) | Histone octomer is wrapped by negatively charged DNA in nucleosome. |
| (d) | Histones are rich in lysine and arginine. |
| (e) | A typical nucleosome contains 400 bp of DNA helix. |