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In a reaction catalyzed by an enzyme, which of the following statements is correct ?
| 1. | Enzymes decrease the activation energy for formation of transition state. |
| 2. | Enzymes make transition form substrate to product more difficult. |
| 3. | Enzymes increase the activation energy for formation of transition state. |
| 4. | Enzyme-substrate complex formed during a reaction lasts for a very long time. |
Other Reason

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