Target DPP Test

1.

Which of the following statements regarding enzyme inhibition is correct?

1.	Competitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein
2.	Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme
3.	Non-competitive inhibition of an enzyme can be overcome by adding large amount of substrate
4.	Non-competitive inhibitors often bind to the enzyme irreversibly

2.

Select the option which is not correct with respect to enzyme action.

1.	Substrate binds with enzyme as its active site
2.	Addition of lot of succinate does not reverse the inhibition of succinic dehydogenase by malonate.
3.	A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate
4.	Malonate is a competitive inhibitor of succinic dehydrogenase

3.

Which of the following secondary metabolites is an anticancer drug?
1. Vinblastin
2. Concanavalin A
3. Abrin
4. Ricin

4.

In an average composition of a cell, the maximum % of total cellular mass [after water and protein] is constituted by:
1. Carbohydrates
2. Lipid
3. Nucleic acids
4. Ions

5.

Given below is the graph showing the effect of substrate concentration on enzyme activity. In the presence of a competitive inhibitor, when the concentration of the substrate is progressively increased:

1.	The K_m value increases but the reaction will not achieve V_max
2.	The K_m value increases but the reaction can ultimately achieve V_max
3.	The K_m value decreases but the reaction will not achieve V_max
4.	The K_m value decreases but the reaction can ultimately achieve V_max

6.

The compound shown below:

1. is a component of the ATP molecule
2. is most commonly found in ori region of DNA
3. can have enzymatic activity
4. may be a component of the cell membrane

7.

Given below is the diagrammatic representation of one of the categories of small
molecular weight organic compounds in the living tissues. Identify the category shown
and the one blank component X in it

Category Component
1. Cholesterol Guanin
2. Amino acid NH₂
3. Nucleotide Adenine
4. Nucleoside Uracil

8.

Which one of the following structural formulae of two organic compounds is correctly
identified with its related function?

1. A - triglyceride major - a source of energy
2. A - Lecithin - a component of cell membrane
3. B - Adenine - forms nucleotides of the nucleic acids
4. Both 2. and 3.

9.

In a 50 gm living tissue, what would be the amount of water?
1. 15-25 gm
2. 25-30 gm
3. 35-45 gm
4. 70-90 gm

10.

In a normal adult, ascending order of concentration of following molecules is
1. Na>K>Fe>Cu
2. Na>K>Cu>Fe
3. Fe>Na>K>Cu
4. Na>Fe>K>Cu

11.

The quaternary structure of a protein:

1.	Consists of 4 subunits - hence the name quaternary
2.	Is unrelated to the function of the protein
3.	Both (a) and (b)
4.	Depends on the 1° structure of subunits

12.

Which one is false?
1. Fatty acids may be unsaturated (with one or more C = C bonds) or a saturated (without double bonds)
2. Fatty acid(s) may be esterified with glycerol forming monoglyceride, diglyceride and then triglyceride
3. Some tissues especially neural tissues have lipids with very simple structures
4. Fats and oils are triglycerides

13.

Which of the following statements about enzymes is true?

1. Enzymes do not alter the overall change in free energy for a reaction
2. Enzymes are proteins whose three dimensional shape is key to their functions
3. Enzymes speed up reactions by lowering activation energy
4. Enzyme are highly specific for reactions
5. An enzyme like any protein has the secondary and tertiary structure.
6. The energy input needed to start a chemical reaction is called activation energy

1. All are correct
2. All except 5
3. 5 and 6
4. 2 and 4

14.

How many types of nitrogenous bases are present in nucleic acid
1. 4
2. 3
3. 5
4. 6

15.

Which of the following is present as a store house of energy in animal tissues?
1. Cellulose
2. Sucrose
3. Glycogen
4. Starch

16.

The number of correct statements amongst the given statements is:
I. Amino acids are substitute methanes.
II. The R group in serine is hydroxyl-methyl.
III. Arachidonic acid has 20 carbon atoms including the carboxyl carbon.
IV. Glycerol is trihydroxypropane.
V. Lecithin is a phospholipid.
1. 2
2. 3
3. 4
4. 5

17.

Which of the following is the simplest amino acid?
1. Alanine
2. Asparagine
3. Glycine
4. Tyrosine

18.

How many groups of the methane can be substituted to form an amino acid Glycine.
1.4
2.3
3.2
4.1

19.

Which group of the amino acid contributes essentially to the chemical and physical properties of amino acids?
1.Amino group
2.Carboxyl group
3.Alkyl group (R group)
4.All of these

20.

Which of the following is true about Lipids
1.It is a polymer of Fatty acids and Glycerol
2.Water soluble
3.Fatty acids can be saturated or unsaturated
4.both 1 and 3

21.

The least abundant element present in human body is
1. Oxygen
2. Carbon
3. Nitrogen
4. Hydrogen

22.

Which of the following is incorrect?
1. Enzymatic activity is maximum at its optimim p^H and temperature.
2. Enzymatic activity declines both below and above the optimum value.
3. Low temperatures destroys enzymatic activity
4. High temperatures destroys enzymatic activity

23.

Electron transferring enzymes belongs to which class of enzymes
1. Transferases
2. Oxidoreductases
3. Isomerases
4. Lyases

24.

About 98% of the mass of every living organism is composed of just six elements including carbon, hydrogen, nitrogen, oxygen and:
1. Phosphorous and sulphur
2. Sulphur and magnesium
3. Magnesium and sodium
4. Calcium and phosphorous

25.

When chemical analysis of living tissue was done using trichloroacetic acid, then the filtrate formed was
1. acid insoluble fraction
2. acid soluble fraction
3. retentate
4. Both (1) and (3)

26. Look at the graph given below. The reaction rate the reaction can be increased beyond point C by:

1. increasing the amount of substrate
2. adding more water
3. increasing the temperature
4. decreasing enzyme concentration

27.

What level of protein organization structure explains the 3-D shape of an enzyme?

1.	primary structure
2.	tertiary structure
3.	secondary structure
4.	quaternary structure

28.

During catalytic cycle of an enzyme–

1.	Enzyme alter its shape to fit the substrate molecule.
2.	Substrate alter its shape to get fit into the enzyme molecule.
3.	Both enzyme and substrate changes its shape during transition state.
4.	Enzyme and substrate are rigid molecular structure and it never changes its shape.

29.

Nucleotides are building blocks of nucleic acids. Each nucleotide is a composite molecule formed by

1.	base-sugar-phosphate
2.	base-sugar-OH
3.
4.	sugar-phosphate

30.

The blood concentration of blood glucose in a normal healthy human ranges between:
1. 4.5 – 5.0 mM
2. 45 – 50 mM
3. 70 – 100 nM
4. 100 – 150 mM

31.

Transferases do not catalyze the transfer of the following group between a pair of substrates:

1. Glycosyl	2. Amine
3. Carboxyl	4. Hydrogen

32.

An example of protein with quaternary structure is
1. Myoglobin
2. Hemoglobin
3. Keratin
4. All of these

33.

Identify the structure of the amino acid that is a Zwitter ion :

1.		2.
3.		4.

34.

Similarity between Inulin, Lecithin and Insulin is -

1.	All are polymeric compound.
2.	All are natural polypeptides.
3.	All contains C,H,O and N.
4.	None of these.

35.

Prosthetic groups differ from co-enzymes, in which:

1.	they require metal ions for their activity.
2.	they (prosthetic groups) are tightly bound to apoenzymes.
3.	their association with apoenzymes is transient.
4.	they can serve as co-factors in a number of enzyme-catalyzed reactions.

36.

Study the given statements -

i.	A dehydration reaction (or condensation reaction) is the process in which water molecules are produced as a polymer is formed from monomers.
ii.	The four main categories of macromolecules present in living systems are proteins, nucleic acids, carbohydrates, and lipids.
iii.	Glucose is the main monosaccharide used by human cells for energy.
iv.	The building blocks or monomers of nucleic acid molecules are called nucleosides.

How many statements are correct?
1. i
2. ii
3. iii
4. iv

37.

Which one of the following biomolecules is correctly characterized?
1. Lecithin – a phosphorylated glyceride found in cell membrane
2. Palmitic acid – an unsaturated fatty acid with 18 carbon atoms
3. Adenylic acid – adenosine with a glucose and phosphate molecule
4. Alanine amino acid – contains an amino group and an acidic group anywhere in the molecule

38.

Which of the following is not a secondary metabolite?
1. Antibiotics
2. Vitamins
3. Carotenoids
4. Morphine

39.

Which of the following monosaccharide is pentose sugar?

1.	Mannose	2.	Ribose
3.	Galactose	4.	Glucose

40.

Cytidine is a/an

1.	Nucleoside
2.	Nucleotide
3.	Essential amino acid
4.	Non essential amino acid

41.

The molecule that provides stability to cell membrane is

42.

The molecule represented is :-

1.	uridine and it is pyrimidine
2.	uridylic acid and it is nucleoside
3.	uridylic acid and it is nucleotide
4.	uridine and it is nucleoside

43.

An aromatic amino acid which is not an essential amino acid is the precursor of catecholamines [adrenaline/noradrenaline/dopamine] and also involved in the synthesis of iodothyronines is:
1. Tryptophan
2. Threonine
3. Phenylalanine
4. Tyrosine

44.

Match the following:

(a)	Inhibitor of catalytic activity of succinate dehydrogenase	(i)	Ricin
(b)	Possess peptide bonds	(ii)	Malonate
(c)	Cell wall material in fungi	(iii)	Chitin
(d)	Secondary metabolite	(iv)	Collagen

Choose the correct option from the following:

	(a)	(b)	(c)	(d)
1.	(iii)	(i)	(iv)	(ii)
2.	(iii)	(iv)	(i)	(ii)
3.	(ii)	(iii)	(i)	(iv)
4.	(ii)	(iv)	(iii)	(i)

45.

Select the incorrect statement.

1.	Dietary proteins are the source of essential amino-acids.
2.	Concanavalin A is a lectin and is considered a secondary metabolite
3.	Cellulose, inulin, starch and glycogen are homopolymers of glucose
4.	Phosphodiester bonds are a characteristic feature of both RNA and DNA

46.

Zwitterions are ionized species of
1. Acidic amino acids
2. Basic amino acids
3. Neutral amino acids
4. All of these

47.

Which of the following is mismatched?

1.	Chitin - Polymer of glucosamine
2.	Glycogen - Polymer of glucose
3.	Cellulose - Heteropolysaccharide
4.	Inulin - Homopolysaccharide

48.

Antibodies that help to fight infectious agents are
1. Polysaccharides
2. Amino acids
3. Proteins
4. Glucose

49.

It is said that elemental composition of living organisms and that of inanimate objects (like earth’s crust) are similar in the sense that all the major elements are present in both. Then what would be the difference between these two groups? Choose a correct answer from among the following.

1.	Living organisms have more gold in them than inanimate objects
2.	Living organisms have more water in their body than inanimate objects
3.	Living organisms have more carbon, oxygen and hydrogen per unit mass than inanimate objects
4.	Living organisms have more calcium in them than inanimate objects

50.

Identify a nucleoside containing a pyrimidine base:
1. Adenine
2. Cytidine
3. Guanosine
4. Thymidylic acid

51. Regarding polysaccharides:

I:	Cellulose does not contain complex helices.
II:	Inulin is a polymer of fructose.
III:	Left end of glycogen is the reducing end

1. Only I and II are correct
2. Only I and III are correct
3. Only II and III are correct
4. I, II and III are correct

52. Identify the correct statement:

1.	α amino acids are substituted methanes
2.	Only triglycerides are lipids that are both macromolecules as well as polymers
3.	Cellulose forms secondary helical structures and can hold iodine molecules in the helical portion
4.	Every virus will have both DNA and RNA as its genetic material

53.

Identify the zwitterion configuration of alanine:

1.
2.
3.
4.

54.

Read the following statements on lipids and find out correct set of statements:

a:	Lecithin found in the plasma membrane is a glycolipid.
b:	Saturated fatty acids possess one or more c=c bonds.
c:	Gingely oil has lower melting point, hence remains as oil in winter.
d:	Lipids are generally insoluble in water but soluble in some organic solvents.
e:	When fatty acid is esterified with glycerol, monoglycerides are formed.

Choose the correct answer from the options given below:
1. (a), (b) and (d) only
2. (a), (b) and (c) only
3. (a), (d) and (e) only
4. (c), (d) and (e) only

55. Identify the correct statements:

I:	The level of protein structure organization that provides the positional information of amino acids in a protein is called as the primary structure.
II:	Only right handed helices are observed in proteins seen in living organisms.
III:	Tertiary structure is absolutely necessary for the many biological activities of proteins.

1.	Only I and II	2.	Only I and III
3.	Only II and III	4.	I, II and III

56. Primary proteins are also known as polypeptides, because:
1. they are linear chains.
2. they are polymers of peptide monomers.
3. successive amino acids are joined by peptide bonds.
4. they can assume many conformations.

57. Given below are two statements:

Statement I:	Amino acids have a property of ionizable nature of –NH₂ and –COOH groups, hence have different structures at different pH.
Statement II:	Amino acids can exist as Zwitterionic form at acidic and basic pH.

In the light of the above statements, choose the most appropriate answer from the options given below:

1.	Both Statement I and Statement II are correct.
2.	Both Statement I and Statement II are incorrect.
3.	Statement I is correct but Statement II is incorrect.
4.	Statement I is incorrect but Statement II is correct.

58. Read the statements given below and select the correct option:

(a)	In glycogen, the right end is the reducing one
(b)	Cellulose and starch form complex helices
(c)	Starch is the main structural component of papers made from plant pulp

1.	Statements (a) and (b) are correct while statement (c) is incorrect
2.	Statements (a) and (c) are correct while statement (b) is incorrect
3.	Statements (b) and (c) are incorrect while statement (a) is correct
4.	Statements (a) and (c) are incorrect while statement (b) is correct

59. Assertion (A): All the proteinaceous enzymes have a 3-D structure.
Reason (R): The secondary structure of protein is according to amino acid present inside the polypeptides.

1. Both (A) and (R) are true and (R) is the correct explanation of (A).
2. Both (A) and (R) are true but (R) is not the correct explanation of (A).
3. (A) is true but (R) is false.
4. Both (A) and (R) are false.

60.

Assertion (A):	The exoskeleton of insects is made of chitin.
Reason (R):	Chitin is a homopolysaccharide.

1.	Both (A) and (R) are true and (R) is the correct explanation of (A).
2.	Both (A) and (R) are true but (R) is not the correct explanation of (A).
3.	(A) is true but (R) is false.
4.	Both (A) and (R) are false.

61. How many different proteins does the ribosome consist of?

1.	20	2.	80
3.	60	4.	40

62. Match List - I with List - II

	List-I		List-II
(A)	Terpenoids	(I)	Vinblastin
(B)	Lectins	(II)	Diterpenes
(C)	Drug	(III)	Ricin
(D)	Toxin	(IV)	Concanavalin A

Choose the correct answer from the options given below:

Options:	(A)	(B)	(C)	(D)
1.	II	IV	III	I
2.	II	I	IV	III
3.	II	III	I	IV
4.	II	IV	I	III

63.
Given below are two statements:

Assertion (A):	Enzyme through their active site, catalyse reactions at high rate.
Reason (R):	An active site of an enzyme is a pocket formed always in the quaternary structure of protein into which substrate fits.

1.	Both (A) and (R) are true and (R) is the correct explanation of (A).
2.	Both (A) and (R) are true but (R) is not the correct explanation of (A).
3.	(A) is true but (R) is false.
4.	Both (A) and (R) are false.

64. A multistep chemical reaction, when each of the steps is catalysed by the same enzyme complex or
different enzymes, is called a:

1.	cascade	2.	metabolic pathway
3.	cycle	4.	amphibolic pathway

65. Which of the following is not a pyrimidine?
1. Thymine
2. Uracil
3. Guanine
4. Cytosine

66. Which end of the glycogen molecule is the reducing end?
1. The left
2. The right
3. The right and the left both
4. Neither the right nor the left

67. Almost all enzymes are proteins but a few may be:

1.	nucleic acids	2.	carbohydrates
3.	lipids	4.	metal ions

68. What type of levels of protein structure would be seen only in proteins which are an assembly of more than one polypeptide chain or subunits?

1.	Primary	2.	Secondary
3.	Tertiary	4.	Quaternary

69. Consider the given two statements:

Assertion (A):	Proteins can have a quaternary structure.
Reason (R):	The quaternary structure of a protein is the folding of the protein into a helix.

1.	Both (A) and (R) are True and (R) correctly explains (A)
2.	Both (A) and (R) are True but (R) does not correctly explain (A)
3.	(A) is True but (R) is False
4.	Both (A) and (R) are False

70. Consider the given two statements:

Statement I:	Macromolecules are generally polymers of smaller units called monomers.
Statement II:	Lipids are macromolecules due to their high molecular weight.

1.	Statement I is correct; Statement II is correct
2.	Statement I is correct; Statement II is incorrect
3.	Statement I is incorrect; Statement II is correct
4.	Statement I is incorrect; Statement II is incorrect

71. What distinguishes α-amino acids from other amino acids?

1.	Amino and acidic groups are present on the same carbon atom.
2.	Presence of a hydroxyl group on the R group.
3.	Substitution of the amino group by a carboxyl group.
4.	All four substituents on the α-carbon are identical.

72. What is the role of coenzymes in enzyme activity?

1.	They provide stability to the enzyme structure.
2.	They temporarily bind to the enzyme during catalysis and participate in the reaction.
3.	They permanently attach to the enzyme and form the active site.
4.	They act as inhibitors to regulate the reaction rate.

73. Given below are two statements, one is labeled as Assertion (A) and the other is labeled as Reason (R).

Assertion (A):	Inhibition of succinic dehydrogenase by succinate is an example of competitive enzyme inhibition.
Reason (R):	Succinate closely resembles malonate in structure.

In light of the above statements, choose the correct answer from the options given below:

1.	Both (A) and (R) are True and (R) correctly explains (A).
2.	Both (A) and (R) are True and (R) does not correctly explain (A).
3.	(A) is True, (R) is False.
4.	(A) is False, (R) is True

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