In Hershey and Chase experiment, what finding led to the conclusion that DNA is the genetic material ?

(1) The presence of radioactivity in the bacteria when 35S was used.

(2) The presence of radioactivity in the supernatant when 35S was used.

(3) The presence of radioactivity in the bacteria when 32P was used.

(4) The presence of radioactivity in the supernatant when 32P was used.

Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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The unequivocal proof that DNA is the genetic material was provided by :

(1) Avery, Macleod and McCarty

(2) Hershey and Chase

(3) Meselson and Stahl

(4) Watson and Crick

Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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Which scientists first gave experimental evidence that DNA is the genetic material?

1. Avery, MacLeod , and McCarty who repeated the transformation experiments of Griffith, and chemically characterized the transforming principle.
2. Garrod, who postulated that Alcaptonuria, or black urine disease, was due to a defective enzyme.
3. Beadle and Tatum, who used a mutational and biochemical analysis of the bread mold Neurospora to extablish a direct link between genes and enzymes. 
4. Meselson and Stahl who showed that DNA is replicated semiconservatively.
Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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The final proof for DNA as the genetic material come from the experiments of 

1. Griffith

2. Hershey and chase 

3. Avery, Macleod and McCarty 

4.  Hargobind Khorana 

Subtopic:  Search for Genetic Material:I | Search for Genetic Material: II | Search for Genetic Material |
 85%
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Alfred Hershey and Martha Chase made a big contribution in proving DNA role as the hereditary molecule. The experiment is shown in the diagram. A and C are the presence or absence of radioactivity detected in cells B and D are the presence or absence of radioactivity detected in supernatants cells. Identify A, B, C and D:

(a) A - No Radioactivity (35S) detected in cells; B - Radioactivity (32P) detected in supernatant; C - Radioactivity (35S) detected in cells; D - No Radioactivity in supernatant
(b) A- Radioactivity (35S) detected in cells; B - No Radioactivity (35S) detected in supernatant; C - Radioactivity (32P) detected in cells; D - No Radioactivity in supernatant
(c) A - No Radioactivity (35S) detected in cells; B - Radioactivity (35S) detected in supernatant; C - Radioactivity (32P) detected in cells; D - No Radioactivity in supernatant
(d) A - No Radioactivity (35S) detected in cells; B - Radioactivity (35S) detected in supernatant; C - No Radioactivity (32P) detected in cells; D - Radioactivity in supernatant

Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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If the DNA of this virus was labeled with 32P and the protein of the virus was labeled with 35S, which molecule(s) would be present inside the cells?
(1) 35S and 32P

(2) 35S only

(3) 32P only

(4) Neither molecule would be present inside the cell

Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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Which of the following statements is correct?
I. The biochemical nature of genetic material was not defined from the experiments conducted by Griffith
II. Working on transformation Avery et al concluded DNA is genetic material but not all biologists were convinced
III. RNA is the genetic material in TMV, QB bacteriophage etc.
IV. DNA is the predominant genetic material while RNA performs dynamic functions of messenger adapter
V. Viruses having DNA genome and having shorter life span mutate and evolve faster
(1) All are correct             

(2) I and II             

(3) All except V               

(4) III and IV

Subtopic:  Search for Genetic Material:I | Search for Genetic Material: II | DNA vs RNA as Genetic Material | Search for Genetic Material |
 66%
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If Hershey and Chase had found 'S in both the pellet and the supernatant, the conclusion about the nature of DNA replication would be that:
(1) Protein must be the information molecule

(2) It would be difficult to conclude anything from these results

(3) DNA is the genetic information molecule

(4) Phage must have stuck to the bacteria

Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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Experiments by Avery, Macleod, and McCarty supported DNA as the genetic material by showing that:
(1) Both protein and DNA samples provided the transforming factor

(2) DNA was not complex enough to be the genetic material

(3) Only samples with DNA provided transforming activity

(4) Even though DNA was molecularly simple, it provided adequate variation to act as the genetic material

Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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In Avery, Macleod and McCarty experiment, the transformation of bacteria was inhibited by:

(1) Proteases

(2) RNase

(3) DNAs

(4) None of these

Subtopic:  Search for Genetic Material: II | Search for Genetic Material |
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