The point mutation leading to sickle cell anaemia occurs:

1. at sixth position in the beta chain of haemoglobin
2. at sixth position in the alpha chain of haemoglobin
3. at sixth position in the beta chain of myoglobin
4. at sixth position in the alpha chain of myoglobin

The point mutation in sickle cell anaemia leads to a change in codon. Identify the correct change:

Sickle cell anaemia results from.

1. A chromosomal aberration

2. Non disjunction of autosome

3. A point mutation

4. Blood transfusion reaction

In sickle cell anaemia, the mutant haemoglobin molecule undergoes

A normal woman, whose father had colour blindness, married a normal man. What is the chance of occurrence of colour blindness in the progeny?

1. 25%

2. 50%

3. 100%

4. 74%

Which of the following genotypes could cause Sickle cell anaemia? 

(1) Hbˢ + Hbᴬ

(2) Hbᴬ+ Hbᴬ

(3) Hbˢ + Hbˢ

(4) Both ‘A’ and ‘C’.

In the given below figure what does (a) and (b) represent

1.  GAG, Glumatic acid

2.  GUG, Valine

3.  GAG, Valine

4.  GUG, Glumatic acid 

Given below is the initial amino acids of the beta chain of a hemoglobin molecule. What will be true about this hemoglobin molecule ?

In a person suffering from sickle-cell anaemia, the template strand of sickle-cell Hb(s) gene has a specific nitrogenous base sequence that codes for valine amino acid. The base sequence on template strand is

1. 5’-CAC-3’

2. 5’-GAG-3’

3. 3’-CAG-5’

4. 3’-CAC-5’

Match the following

   Column-l                       Column-ll

a.  Haemophilia               i.  Rudimentary ovaries

b.  Sickle cell anaemia     ii.  X-linked recessive

c.  Turner's syndrome      iii.  Gynaecosmastia

d.  Klinefelter's                iv.  Autosomal recessive 
     syndrom

a.  a(ii), b(iv), c(i), d(iii)

b.  a(ii), b(iv), c(iii), d(i)

c.  a(iv), b(ii), c(i), d(iii)

d.  a(iv), b(i), c(ii), d(iii)