| I: | All diabetics require insulin from the very beginning. |
| II: | Insulin can be given orally to diabetics. |
| III. | Insulin extracted from pancreas of slaughtered cattle and pigs caused some patients to develop allergy. |
| IV. | Recombinant insulin was first prepared by Indian pharmaceutical giant Ranbaxy. |
| V. | The two polypeptide chains in the final structure of Insulin are joined by disulfide bonds. |
| VI. | DNA sequences corresponding to A and B chains of human insulin were introduced in plasmids of E.coli to produce insulin chains for preparing recombinant insulin. |
| 1. | 2 | 2. | 3 |
| 3. | 4 | 4. | 5 |
| Assertion (A): | Gene therapy is a method of treating a disorder but cannot cure it. |
| Reason (R): | Cells are drawn from a patient and the functional gene is introduced into these cells and transferred back to the patient. |
| 1. | Both (A) and (R) are True and (R) is the correct explanation of (A). |
| 2. | Both (A) and (R) are True and (R) is not the correct explanation of (A). |
| 3. | (A) is True but (R) is False. |
| 4. | (A) is False but (R) is True. |
| (a) | Pro-hormone insulin contain extra stretch of C-peptide |
| (b) | A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted and combined by creating disulphide bond between them. |
| (c) | Insulin used for treating Diabetes was extracted from Cattles and Pigs. |
| (d) | Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone. |
| (e) | Some patients develop allergic reactions to the foreign insulin. |
| 1. | (c), (d) and (e) only | 2. | (a), (b) and (d) only |
| 3. | (b) only | 4. | (c) and (d) only |
| (A) | It is a method of cellular defense in all prokaryotic organisms. |
| (B) | This method has been used to make nematode resistant tobacco plants. |
| (C) | It is a post translational method of silencing of genes. |
| 1. | Norman Borlaug is considered as father of green revolution |
| 2. | Green revolution leads to enhanced production of wheat and rice |
| 3. | Techniques used during green revolution led to tripling of the yield |
| 4. | Use of biofertilizers, biopesticides was promoted heavily during green revolution |
| 1. | The production of plants that exhibit large variations from the parent plants. |
| 2. | Quickly production of mature plants. |
| 3. | The regeneration of whole plants from plant cells that have been genetically modified. |
| 4. | Storage of genetic plant material to safeguard native plant species. |
| Assertion(A): | The Green Revolution succeeded in tripling the food supply. |
| Reason (R): | Use of genetically modified crops was primarily responsible for the success of green revolution. |
| 1. | Both (A) and (R) are True and (R) correctly explains (A). |
| 2. | Both (A) and (R) are True but (R) does not correctly explain (A). |
| 3. | (A) is True; (R) is False |
| 4. | Both (A) and (R) are False |
| Assertion(A): | Insulin isolated from other cattle or pigs is not as effective as that secreted by the human body itself. |
| Reason (R): | Insulin isolated from other cattle or pigs will elicit an immune response in the human body |
| 1. | Both (A) and (R) are True and (R) correctly explains (A). |
| 2. | Both (A) and (R) are True but (R) does not correctly explain (A). |
| 3. | (A) is True; (R) is False |
| 4. | Both (A) and (R) are False |